Library Screening Platform Lead (Asian Skin Biobank), A*SRL/SRIS

The A.STAR Skin Research Labs (A.SRL) and Skin Research Institute of Singapore (SRIS) aim to develop novel and efficient products and therapies to prevent age-related loss of skin function, treat skin conditions, and reduce the clinical burden of skin diseases. To facilitate the identification of new hits or tool compounds, the Asian Skin Biobank at SRIS has acquired different compound libraries (natural compounds, FDA-approved drugs, kinase inhibitors) and is looking for a motivated and skilled Scientist/Senior Scientist to set and lead the library screening platform. This position is ideal for an individual with a strong background in cell biology and biochemistry, experience in high throughput drug screening, and solid expertise in skin biology, skin models and cell-based assays for the validation of potential targets.

Key Responsibilities:

• Conceptualize cell- based assays for drug screening and hit identification.
• Design and optimize biochemical cell- based assays with various readouts.
• Develop reporter lines to quantify expression of gene of interests.
• Plan, execute and analyse high throughput screening of library compounds for inter- and intra-institutional collaborations.
• Design and execute in vitro functional assays for hit/target validation.
• Serve as primary point of liaison and coordination between investigators, researchers, sponsoring organizations, and Tech Biz.
• Present findings at internal and external meetings and conferences.
• Write research reports and actively contribute to the preparation of publications.

Requirements:

• PhD degree in Biology, Chemistry, Pharmacy, or a related field.
• At least 5 years of relevant experience in screening of compound libraries, development of specialised cell lines, and cell-based assays.
• Knowledge in skin cell biology and diseases.
• Strong organisational and problem-solving skills.
• Excellent oral and written communication and presentation skills.
• Able to work independently, and as part of a team, with a positive and enthusiastic attitude.