Research Scientist (Mucosal Infection Lab), A*STAR ID Labs

A.STAR Infectious Diseases Labs (A.IDL) is seeking for a Research Scientist to join us in our mission to to be a leading centre for infectious diseases research excellence in antimicrobial resistance, respiratory and vector-borne diseases. A.IDL brings together infectious diseases expertise from across multiple disciplines to drive cutting edge translational infectious diseases research to contribute to Singapores national preparedness.

You will be joining the Mucosal Infection Lab. The lab focuses on modelling mucosal infection using in vitro and in vivo systems with priority antimicrobial resistance (AMR) bacteria to understand disease pathogenesis. Specifically, the projects will involve dissecting the mechanisms in the gut-liver axis during bacterial induced pyrogenic liver abscess. Candidates with prior experience working with liver diseases and single-cell RNAseq are preferred.

Job Responsibilities:

• Basic molecular and protein assay including PCR and ELISA
• Small animal infection with AMR bacteria (Klebsiella pneumoniae and E. coli)
• Small animal microbiome colonization models
• In vitro infection assay using AMR bacteria and microbiome.
• Immune profiling in the tissues of infected animals
• Lab safety and housekeeping
• Routine administrative duties and budget/spending management of the lab

Job Requirements:

• PhD in Biomedical Sciences, Life Sciences, Infectious diseases, Immunology or related field.
• At least 1 year of relevant experience
• Good spoken and written communication skills
• Experience working with liver diseases
• Background with single cell RNAseq
• Competency in bacterial culture, cell culture, flow cytometry and basic microscopy will be advantageous but not strictly required.
• Basic knowledge in bioinformatics will be advantageous.
• Comfortable working with small animal models