Scientist (HWP Lab), IMCB

We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to identify and validate candidates that address the bodys adaptive responses to weight loss.

TaRgeted Analysis of Novel Secreted Factors for Obesity Reduction and Metabolic Health (TRANSFORM)

Description:

Multi-omic analysis of secreted factors from various datasets was carried out, including human, mouse and primate plasma and metabolic tissues to identify novel primate-specific secreted factors critically involved in the regulation of physiology balance. Integrative data analysis and in silico rank scoring revealed a list of promising secreted factor candidates. We will be using model organisms (e.g. mice, zebrafish) to conduct phenotypic screens and prioritize candidates for detailed validation, characterization, mode-of-action studies and therapeutic strategies.

Job responsibilities:

Conduct in vitro wet lab experiments for identified candidates (e.g. cell culture, molecular biology and assays, protein chemistry, pharmacological efficacy etc)

Conduct in vivo screening experiments for prioritized candidates (e.g. in preclinical models of obesity)

Conduct end-point and mechanistic experiments (e.g. target tissue and blood collection, sample preparation etc)

Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings

Interact and collaborate with and assist other researchers and collaborators on related projects

Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction

Assist in the preparation of grant applications and grant process reports

Present findings both orally and in written form via presentations and publication in peer-reviewed journal

Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals

Contribute to other program-related projects and organizations and with the general scientific community across A.STAR